Robaxin Drug Interaction

Most frequently checked interactions

View interaction reports for Robaxin (methocarbamol) and the medicines listed below.

        • Advil (ibuprofen)
        • Aleve (naproxen)
        • Ambien (zolpidem)
        • Benadryl (diphenhydramine)
        • codeine
        • Cymbalta (duloxetine)
        • Flexeril (cyclobenzaprine)
        • gabapentin
        • gabapentin
        • hydrocodone
        • ibuprofen
        • ibuprofen
        • Klonopin (clonazepam)
        • lisinopril
        • Lyrica (pregabalin)
        • metformin
        • Motrin (ibuprofen)
        • naproxen
        • Neurontin (gabapentin)
        • Norco (acetaminophen / hydrocodone)
        • omeprazole
        • oxycodone
        • oxycodone
        • prednisone
        • Synthroid (levothyroxine)
        • tramadol
        • tramadol
        • trazodone
        • Tylenol (acetaminophen)
        • Valium (diazepam)
        • Vicodin (acetaminophen / hydrocodone)
        • Vitamin D3 (cholecalciferol)
        • Xanax (alprazolam)
        • Zoloft (sertraline)
        • Zyrtec (cetirizine)

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.

If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Alfentanil
      • Alprazolam
      • Amobarbital
      • Aprobarbital
      • Benzhydrocodone
      • Bromazepam
      • Buprenorphine
      • Butabarbital
      • Butalbital
      • Butorphanol
      • Calcium Oxybate
      • Cannabidiol
      • Carisoprodol
      • Cetirizine
      • Chloral Hydrate
      • Chlordiazepoxide
      • Chlorzoxazone
      • Clobazam
      • Clonazepam
      • Clorazepate
      • Codeine
      • Dantrolene
      • Diazepam
      • Dihydrocodeine
      • Doxylamine
      • Esketamine
      • Estazolam
      • Ethchlorvynol
      • Fentanyl
      • Flibanserin
      • Flunitrazepam
      • Flurazepam
      • Gabapentin
      • Gabapentin Enacarbil
      • Halazepam
      • Hydrocodone
      • Hydromorphone
      • Ketamine
      • Ketazolam
      • Lemborexant
      • Levorphanol
      • Lofexidine
      • Lorazepam
      • Lormetazepam
      • Loxapine
      • Magnesium Oxybate
      • Medazepam
      • Meperidine
      • Mephenesin
      • Mephobarbital
      • Meprobamate
      • Metaxalone
      • Methadone
      • Methohexital
      • Metoclopramide
      • Midazolam
      • Morphine
      • Morphine Sulfate Liposome
      • Nalbuphine
      • Nitrazepam
      • Oxazepam
      • Oxycodone
      • Oxymorphone
      • Pentazocine
      • Pentobarbital
      • Periciazine
      • Phenobarbital
      • Potassium Oxybate
      • Prazepam
      • Pregabalin
      • Primidone
      • Quazepam
      • Remifentanil
      • Remimazolam
      • Scopolamine
      • Secobarbital
      • Sodium Oxybate
      • Sufentanil
      • Tapentadol
      • Temazepam
      • Thiopental
      • Tramadol
      • Trazodone
      • Triazolam
      • Zolpidem

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease or
  • Liver disease—Use with caution. The effects of this medicine may be increased because of slower removal from the body.
  • Myasthenia gravis—Use with caution. May make this condition worse.

Proper use of Robaxin-750

This section provides information on the proper use of a number of products that contain methocarbamol. It may not be specific to Robaxin-750. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For relaxing stiff muscles:
      • Adults—At first, three tablets of 500 milligrams (mg) or two tablets of 750 mg (total dose of 1500 mg) four times a day. Your doctor may adjust your dose as needed.
      • Children—Use and dose must be determined by your doctor.